Xevinapant hydrochloride

Cat. No.: IBDI-434870

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAP; s). Xevinapant hydrochloride binds to XIAP; , cIAP; 1, and cIAP; 2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP; BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP; 1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors.

Product Details

Target	IAP | Apoptosis
Molecular Weight	598.18
Appearance	Solid
Synonyms	AT-406 hydrochloride, Debio 1143 hydrochloride, SM-406 hydrochloride
SMILES	O=C([[email protected]@H]1CC[[email protected]@](CCN(C(CC(C)C)=O)C[[email protected]@H]2NC([[email protected]@H](NC)C)=O)([H])N1C2=O)NC(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl
Purity	98.80%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.