XL01126

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Cat. No.: IBDI-434933

XL01126 is a potent degrader of LRRK2 with DC50s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research. XL01126 exerts function of study of non-catalytic and scaffolding functions of LRRK2.

Size (Solid):

Product Details

Target	PROTACs \| LRRK2
Molecular Weight	1019.69
Appearance	Solid
SMILES	O=C([[email protected]]1N(C([[email protected]@H](NC(C2(F)CC2)=O)C(C)(SC[[email protected]@H]3CC[[email protected]@H](CN4CCN(C(C5=CC=C(NC6=NC=C(Cl)C(NC)=N6)C(OC)=C5)=O)CC4)CC3)C)=O)C[[email protected]](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Purity	99.81%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.