YF135

Cat. No.: IBDI-432926

YF135 is an efficient and reversible-covalent KRAS G12C PROTAC. YF135 is designed and synthesized by tethering KRAS G12C inhibitor 48 (compound 6d) as the ligand, and basing on the scaffold of MRTX849 linkage VHL ligand. YF135 significantly induces the degradation of KRAS G12C in a reversible manner and decreases phospho-ERK level through the E3 ligase VHL mediated proteasome pathway.

Product Details

Target	PROTACs | PERK
Molecular Weight	1179.86
SMILES	CC1=C(SC=N1)C2=CC=C(C=C2)CNC([[email protected]@H]3C[[email protected]](CN3C([[email protected]](C(C)(C)C)NC(CCOCCCN4CCC[[email protected]]4COC5=NC6=C(C(N7CCN([[email protected]](C7)CC#N)C(/C(C#N)=C/C8CC8)=O)=N5)CCN(C6)C9=CC=CC%10=C9C(Cl)=CC=C%10)=O)=O)O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.