YM458

Cat. No.: IBDI-432896

YM458 is a potent EZH2 and BRD4 dual inhibitor with IC50s of 490 nM and 34 nM, respectively. YM458 inhibits cell proliferation and colony formation and induces cell cycle arrest and apoptosis in solid cancer cells. YM458 can be used for researching anticancer.

Product Details

Target	Histone MethylTransfeRase | Epigenetic Reader Domain | Apoptosis
Molecular Weight	957.62
SMILES	CC1=C(C2=C(S1)N3C([[email protected]@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCCCCOC5=CC=C(C6=CC(N(CC)C7CCOCC7)=C(C(C(NCC8=C(C=C(NC8=O)C)C)=O)=C6)C)C=C5)=O)=NN=C3C)C

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.