(Z)-SMI-4a

Cat. No.: IBDI-436176

(Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 µM. (Z)-SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity.

Product Details

Target	Pim
Molecular Weight	273.23
Synonyms	(Z)-TCS-PIM-1-4a
SMILES	O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.