ZC3H12D Polyclonal Antibody

Target Information

Target Name	ZC3H12D
Uniprot ID	A2A288
Cellular Localization	Cytoplasm. Nucleus; Cytoplasm. Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm and Cytoplasm, P-body. Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).
Immunogen	A 16 amino acid peptide from the intermediate residues of Human ZC3H12D protein.
Function	May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).

Product Details

Description	Rabbit polyclonal antibody to ZC3H12D.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	A 16 amino acid peptide from the intermediate residues of Human ZC3H12D protein.
Positive Control	WB: Fetal small intestine lysate and fetal spleen lystae IHC-P: Fetal small intestine
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.02% Sodium Azide Constituent: 0.5% BSA, PBS
Handling	Avoid freeze-thaw cycles.