ZYF0033

Cat. No.: IBDI-437865

ZYF0033 (HPK1-IN-22, compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 decreases the phosphorylation of SLP76 (serine 376). ZYF0033 promotes anticancer immune responses. ZYF0033 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a +CD8 + T cells but decreased infiltration of regulatory T cells, PD-1 +CD8 + T cells, TIM-3 +CD8 + T cells, and LAG3 +CD8 + T cells in the 4T-1 syngeneic mouse model.

Product Details

Target	MAP4K
Molecular Weight	462.61
Synonyms	HPK1-IN-22
SMILES	OC(C)(C)C#CC1=CC=CC(COC2=C(N)N=CC(C3=CN=C(C4CCN(CC4)C)S3)=C2)=C1

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.