Accelerate Your IBD Research with Our DSS-Induced Acute Colitis Model

Reliable animal models are essential for understanding inflammatory bowel disease (IBD) pathophysiology and for evaluating the efficacy of novel therapeutic candidates. Our DSS-Induced Acute Colitis Model is a well-validated, reproducible in vivo system designed to mimic key clinical and histopathological features of human IBD.

Model Overview

In this study, C57BL/6 mice were administered 3% DSS in drinking water for 10 consecutive days, inducing acute colitis characterized by rapid onset of intestinal inflammation. Disease progression and treatment response were monitored using a comprehensive panel of clinically relevant endpoints, providing a translational framework for efficacy testing.

Comprehensive Readouts and Analytical Capabilities

The case study highlights a multidimensional evaluation strategy, including:

• Disease Activity Index (DAI)

  Continuous monitoring of body weight loss, stool consistency, and fecal bleeding.

• Colon Morphology

  Assessment of colon length, weight, and weight-to-length ratio as indicators of inflammation severity.

• Histopathological Analysis

  H&E staining and histopathological scoring to evaluate mucosal damage, ulceration, inflammatory cell infiltration, goblet cell depletion, and crypt architecture disruption.

Why Download This Case Study?

By downloading this case study, you will learn:

• How to establish a reproducible DSS-induced acute colitis model
• Which clinical, anatomical, and histological endpoints best reflect disease severity
• How to evaluate anti-inflammatory and immunomodulatory compounds in vivo
• How this model can support lead optimization, MoA studies, and translational research
• How customized animal models can de-risk IBD drug development pipelines

Explore how our DSS-Induced Acute Colitis Model can help you generate robust, decision-enabling data and accelerate your preclinical IBD research.

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