Inflammatory Pain Model Development Services
Ace Therapeutics is a preclinical contract research organization dedicated to supporting pharmaceutical and biotechnology companies in the development of analgesics. Our specialized services focus on the application of validated animal models of inflammatory pain, designed to mimic clinical pain conditions and provide robust platforms for drug screening, efficacy assessment, mechanistic investigation, and early-stage toxicology and pharmacokinetic (PK) evaluations.
Inflammatory pain results from tissue damage and immune activation, often observed in conditions such as arthritis, postoperative pain, or infection-induced inflammation. Modeling these complex pathologies in animals provides a critical foundation for identifying and optimizing novel therapeutic agents.
Our inflammatory pain-related CRO services follow a comprehensive and structured pipeline
To ensure the selection of the most predictive and translational model, Ace Therapeutics provides a consultation-based model screening process, including:
These early-stage studies are critical for de-risking your compound development and selecting optimal downstream assays.
We implement well-characterized inflammatory pain models tailored to mimic clinical scenarios of tissue injury or immune activation.
| Model Name | Induction Method | Pain Type | Use Cases |
| CFA-induced model | Complete Freund’s Adjuvant injection | Persistent inflammation | Osteoarthritis, rheumatoid arthritis |
| Carrageenan model | λ-carrageenan injection into paw | Acute inflammation | NSAIDs and steroid evaluation |
| Zymosan model | Zymosan A intra-articular injection | Joint inflammation | Synovitis-targeted compounds |
| Formalin test | Subcutaneous formalin injection | Biphasic pain response | Central and peripheral mechanisms |
| Adjuvant-induced arthritis | Systemic immunization | Chronic polyarthritis | Autoimmune models for DMARDs |
Using validated behavioral paradigms and quantitative endpoints, we provide dose-response and efficacy assessments of investigational analgesics.
To elucidate the molecular basis of drug action or pain resolution mechanisms, we offer targeted and exploratory studies:
While early-stage exploratory toxicology and PK data are often required to support further development, our services focus on non-GLP exploratory studies that align with the objectives of early decision-making.
These services can be seamlessly integrated into efficacy studies for cost-effective development.
Our inflammatory pain models and services are suitable for evaluating a broad spectrum of drug candidates:
| Drug Class | Potential Evaluation |
| NSAIDs | Peripheral anti-inflammatory effects |
| Opioids | Central and peripheral analgesia |
| Biologics | Target-specific anti-inflammatory activity |
| Ion channel modulatorst | Neuropathic and inflammatory modulation |
| Cytokine inhibitors | Disease-modifying potential |
| Natural products | Mechanism-based screening and validation |
To learn more about how our inflammatory pain models can support your analgesic development program, reach out to the Ace Therapeutics team. Our scientists are available to discuss model selection, study design, and integration with your pipeline goals.
What is the typical timeline for a full inflammatory pain efficacy study?
The timeline depends on the model selected and study scope. Acute models can be completed more quickly, while chronic models such as adjuvant-induced arthritis require extended observation periods.
Can you customize a model for my compound’s target mechanism?
Yes. We offer model customization services, including alternative induction methods, transgenic animals, or molecular endpoints tailored to your mechanism of interest.
What species are commonly used for inflammatory pain models?
We primarily use Sprague-Dawley rats and C57BL/6 or BALB/c mice, depending on the pharmacokinetics and molecular targets of the investigational agent.
Can behavioral data be correlated with molecular endpoints?
Yes. We routinely offer integrated behavioral-molecular study designs to provide a comprehensive understanding of drug effects.
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Conclusion
Ace Therapeutics comprises a team of highly committed and skilled researchers focused exclusively on providing innovative preclinical contract research solutions for novel analgesic development. We deliver rigorous models and data essential for advancing targeted, non-addictive pain therapies toward clinical evaluation.