Mouse Model of Dextran Sodium Sulfate (DSS)-induced Colitis
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Mouse Model of Dextran Sodium Sulfate (DSS)-induced Colitis

The dextran sodium sulfate (DSS) induced colitis model is a relatively simple and very widely used model of experimental colitis. This protocol provides a detailed description of procedures, important considerations when performing the protocol.

Unlock Reliable Preclinical Insights with Our DSS-Induced Colitis Model Protocol

Why Download Our DSS-Induced Colitis Protocol?

Our comprehensive protocol document offers more than just step-by-step experimental guidance. It is designed as a practical resource for academic researchers, pharmaceutical companies, and biotech innovators who are advancing IBD research and drug development. Key highlights include:

Detailed Experimental Design

  • Guidelines for animal selection, housing, and acclimatization.
  • Optimized DSS administration methods, including concentration, duration, and route of exposure.
  • Flexible model induction strategies to mimic both acute and chronic colitis.

Clinical Assessments

  • Scoring systems for disease activity index (DAI), body weight, stool consistency, and rectal bleeding.

Pathological and Molecular Readouts

  • Colon length and gross morphology evaluation.
  • Histopathological scoring systems for epithelial damage, mucosal ulceration, and immune cell infiltration.
  • Cytokine profiling, gene expression analysis, and immune cell characterization to support mechanistic studies.

Who Should Download This Protocol?

  • Academic researchers exploring IBD mechanisms or testing proof-of-concept therapies.
  • Pharmaceutical and biotech companies developing novel therapeutics for ulcerative colitis, Crohn's disease, or related GI disorders
  • Preclinical CROs and R&D teams seeking standardized and validated workflows for reliable study execution.

Get Your Copy Today

By downloading our mouse model of DSS-induced colitis protocol, you will gain access to a meticulously curated resource that integrates methodological rigor with practical tips, ensuring consistency and reliability in your preclinical IBD studies. Whether you are designing your first colitis experiment or optimizing therapeutic pipelines, this protocol will serve as a cornerstone for your research.