In Vitro Models of IBD

In Vitro Models of IBD

In vitro models of IBD are crucial for studying the disease's mechanisms and developing new therapies. These models, ranging from simple cell cultures to more complex 3D and organoid systems, allow researchers to investigate the intricate interplay between immune cells, epithelial cells, and the gut environment in a controlled setting.

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Unlock Insights into IBD Research with Our In Vitro Models of IBD Case Study

Explore how Ace Therapeutics accelerates IBD research with co-culture model of NCM460/THP-1 cells and intestinal organoids model. This poster offers an in-depth case study and showcases our capabilities in modeling complex immune and epithelial interactions critical to IBD pathology. Discover how our platform can support your preclinical programs with data-driven confidence.

Step-by-Step Protocol Transparency

From cell culture and immune differentiation (e.g., PMA-induced THP-1 macrophages) to co-culture timelines and treatment regimens, each step is standardized for consistency and reproducibility.

Strict and Multimodal Validation Data

Focuses on core experimental outcomes, providing directly applicable empirical support for protocol design:

Morphology observation of organoids: In our intestinal organoid model, morphology observation provides critical visual confirmation of structural integrity and responsiveness to treatment.
Barrier integrity assessment: TEER measurement and tight junction protein staining (e.g., ZO-1 via immunofluorescence) quantify epithelial barrier function and disruption.

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In Vitro Models of IBD

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