Unlock Insights into IBD Research | Specialized Experimental Model Solutions

The acetic acid-induced colitis model reliably reproduces the key clinical and pathological features of ulcerative colitis (UC), enabling rapid evaluation of therapeutic candidates and mechanistic insights into intestinal inflammation and mucosal repair.

Why Choose Our Acetic Acid-Induced Colitis Models?

• Clinically Relevant Pathophysiology: Our acetic acid-induced colitis model closely mirrors key features of human ulcerative colitis, including epithelial injury, mucosal necrosis, ulceration, and infiltration of inflammatory cells such as neutrophils.
• Rapid and Reproducible Induction: Through a single rectal administration of diluted acetic acid, inflammation is consistently induced within days.
• Flexible Study Design for Multiple Species:
  • Murine model: BALB/c mice with 3% acetic acid induction—ideal for early-phase efficacy testing.
  • Canine model: Beagle dogs with 7% acetic acid induction—suited for advanced translational studies and comparative pathology.

Comprehensive Readouts and Analytical Capabilities

• Clinical parameters: Body weight, stool consistency, fecal blood, and Disease Activity Index (DAI).
• Macroscopic evaluation: Colon length and weight, mucosal congestion, and ulceration scoring.
• Histopathology: Detailed H&E and IHC evaluation of epithelial erosion, neutrophil infiltration, and edema.
• Biochemical analysis: Myeloperoxidase (MPO) activity, cytokines (TNF-α, IL-1β, IL-6, IL-10), and oxidative stress markers (MDA, GSH, SOD).

Accelerate your ulcerative colitis research with our validated acetic acid-induced colitis model. Download the brochure to discover how Ace Therapeutics can help advance your preclinical IBD research.

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