Unlock Insights into IBD Research | Specialized Experimental Model Solutions

Reliable preclinical models are critical for understanding intestinal inflammation and evaluating the efficacy of novel therapeutics for inflammatory bowel disease (IBD). Our Indomethacin-Induced Intestinal Inflammation Model is a well-established in vivo platform that reproduces key pathological features of small intestinal inflammation, including mucosal injury, barrier dysfunction, immune activation, and inflammatory cytokine production.

Model Overview

The indomethacin-induced intestinal inflammation model is established through administration of the non-steroidal anti-inflammatory drug (NSAID) indomethacin, resulting in reproducible small intestinal injury characterized by ulceration, inflammatory cell infiltration, increased intestinal permeability, and activation of pro-inflammatory signaling pathways.

Comprehensive Readouts and Endpoints

The poster highlights a broad range of in-life, molecular, and pathological-based assessments, including:

• Clinical and In-Life Assessments
  Body weight monitoring, inflammation severity scoring, general health and disease progression evaluation
• Histopathological Analysis
  Small intestinal H&E staining, immunohistochemistry (IHC), assessment of mucosal injury, ulceration, and inflammatory infiltration
• Inflammatory Biomarker Evaluation
  Pro-inflammatory cytokine analysis, myeloperoxidase (MPO) activity assessment, fecal inflammatory biomarker measurements
• Immune and Molecular Profiling
  Peripheral immune cell characterization, intestinal lamina propria immunophenotyping, gene and protein expression analysis

Applications in IBD Drug Development

By downloading this brochure, you'll learn how the Indomethacin-Induced Intestinal Inflammation Model supports:

• Evaluation of anti-inflammatory and immunomodulatory therapies
• Assessment of mucosal protective agents
• Investigation of intestinal barrier dysfunction
• Mechanistic studies of inflammation and tissue injury
• Biomarker discovery and validation
• Gastrointestinal safety assessment
• Translational research for Crohn’s disease and related intestinal disorders

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