Alzheimer's Disease Preclinical Research Solutions

Empowering Your Alzheimer's Disease Research

Our diverse range of optimized in vitro and in vivo models, combined with robust assays, delivers valuable insights for your Alzheimer's disease studies. Whether you start with our cell-based models, transgenic mouse models, aged rodent models, or amnesia-induced models, each system reflects the critical pathologies of Alzheimer's. Build on these foundations with our comprehensive platform of neuroscience tools and assays, including advanced cognitive studies and AD-related pathology assessments. Ace Therapeutics is dedicated to providing the actionable data that will accelerate your Alzheimer's drug development.

Comprehensive Alzheimer's Disease Research Solutions

Our service package consists of established cell-based models, genetically engineered mouse models, and aged rodent models validated to recapitulate hallmark features of Alzheimer's disease, such as amyloid plaques, neurofibrillary tangles, synaptic loss, and cognitive dysfunction. When combined with our new neuroimaging technologies and wide biomarker analysis, Ace Therapeutics is the one that offers high-quality reproducible data in support of your drug development strategy in Alzheimer's disease.

Advanced Models for Alzheimer's Disease Research

Comprehensive Behavioral & Cognitive Evaluations

Advanced Pathological Diagnostic Tools

Efficient Study Launch Process

Customized Research Frameworks

Specialized Research Coordination Support

Available transgenic and non-transgenic options model specific pathologies such as amyloid-beta plaques and tau aggregation. For ideal alignment to your research goals, we recommend contacting our neurology experts to discuss tailor-fit model selection

Transgenic Mouse Models

5xFAD Mice
Tg2576 Mice
3xTg-AD Mice

Pharmacological Models

Scopolamine-Induced Amnesia Model
Aβ Oligomer-Induced Model

Aged Rodent Models

Naturally aged rats and mice provide a physiological model of age-related cognitive decline and neurodegeneration.

Non-Rodent Models

Large animal models, including aged canine and non-human primates.

Human iPSC-Derived Models

Wild-type and disease-specific neurons, microglia, and astrocytes for in vitro studies.
Co-culture systems to study neuron-glia interactions and neuroinflammation.

*Please note, these models are only available for use in studies conducted through Ace Therapeutics, they are not available to purchase independently.

Don't See Your Model? We've Got You Covered!

Our team specializes in customized solutions to address your specific research challenges.
Let's collaborate to design the ideal approach for your project.

Comprehensive Assays and Screening

Our complete range of assay services includes hit identification, lead optimization, mechanism of action, and efficacy testing.

Behavioral and Cognitive Testing

Behavioral studies play an important role in ascertaining the therapeutic efficiency of the drug candidates in causing desired modifications in the cognitive dysfunction associated with AD.

Morris Water Maze
Radial Arm Water Maze
Fear Conditioning
Y-Maze
Elevated Plus Maze and Marble Burying

Preclinical Neuroimaging

We characterize structural and functional brain changes associated with Alzheimer's disease by in vivo neuroimaging methods.

MRI
PET Imaging
Functional Ultrasound
Magnetic Resonance Spectroscopy (MRS)

Biomarker Discovery and Analysis

We offer comprehensive biomarker analysis as adjunctive tools for neuroimaging and behavioral tests

Immunohistochemistry
Cytokine and Chemokine Profiling
Quantification of Neurofilament light chain (NfL)
Protein Expression Assays
Real-time Monitoring of Neurotransmitters and Pharmacokinetics

Translational Neuroscience Tools

Our comprehensive approach uses the cutting-edge translational neuroscience tools that can bridge the gap between preclinical research and actionable insights to drive therapeutic discovery forward.

Mechanism of Action Studies
Target Engagement and Pathway Analysis
Pharmacodynamic and Pharmacokinetic Profiling
DMPK/ADME Services
Blood-Brain Barrier Permeability Assessment
Metabolite Identification and Toxicity Screening

Why Choose Ace Therapeutics?

Expertise

Our neuroscientists, pharmacologists, and translational researchers have decades of experience in Alzheimer's disease research.

Innovation

We employ the latest technologies and methodologies to ensure high-quality, reproducible data.

Collaboration

We'll work closely with you to design your customized study so that they respond to the research questions that are relevant to you.

Speed and Efficiency

We maintain fast turnaround times without compromising the integrity of your data by streamlined workflow.

Frequently Asked Questions (FAQ)

What models are good for studying neuroinflammation in Alzheimer's disease?

Our 5xFAD and 3xTg-AD mouse models display strong neuroinflammatory responses, including microglial activation and cytokine release. Furthermore, our human iPSC-derived microglia and astrocyte co-culture systems are a robust in vitro platform for the study of neuroinflammation.

Can Ace Therapeutics support large animal studies for Alzheimer's disease research?

Yes, we have aged non-human primate and canine models for advanced translational studies in cognitive touchscreen-based testing and biomarker analysis.

How do you ensure the reproducibility of behavioral tests?

Our protocols for behavioral testing are standardized and validated across multiple studies. Besides that, automated tracking systems and/or blinded study design reduce variability.

What endpoints do you recommend for electrophysiology studies in AD models?

We suggest studying basal synaptic transmission and LTP since synaptic dysfunction is one of the hallmarks of Alzheimer's disease.