Preclinical Neuroimaging Services

Alzheimer's disease is a complex neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, tau tangles, and progressive brain atrophy. At Ace Therapeutics, we specialize in preclinical neuroimaging to visualize and quantify disease progression in animal models, providing researchers with unparalleled insights into AD mechanisms and therapeutic efficacy.

Why Preclinical Neuroimaging?

Neuroimaging bridges the gap between cellular pathology and functional outcomes, offering a non-invasive window into the living brain. By combining advanced imaging technologies with validated AD models, we help researchers

• Track Aβ and tau deposition in real time.
• Monitor hippocampal atrophy and white matter integrity.
• Assess cerebral blood flow and metabolic changes.

Core Neuroimaging Services

Amyloid and Tau Imaging

Aβ plaques and tau tangles are hallmarks of AD. We use cutting-edge techniques to visualize these pathologies

• Amyloid-PET Imaging
  Quantify Aβ burden in transgenic models like APP/PS1 and 5xFAD mice using radiotracers such as Pittsburgh Compound B (PiB).
• Tau PET Imaging
  Track tau spread in tauopathy models with tracers like MK-6240 or flortaucipir.
• Optical Imaging

Structural and Functional MRI

Our services include

• High-Resolution MRI (7T/9.4T)
  Measure hippocampal atrophy, cortical thinning, and ventricular enlargement in AD models.
• Diffusion Tensor Imaging (DTI)
  Assess white matter integrity and track axonal degeneration.
• Resting-State fMRI
  Map functional connectivity changes in networks affected by AD, such as the default mode network.

Cerebral Blood Flow and Metabolism

Vascular and metabolic dysfunction play key roles in AD. We evaluate these aspects using

• Arterial Spin Labeling (ASL)
  Quantify cerebral blood flow changes in models of vascular contributions to AD.
• FDG-PET Imaging
• Magnetic Resonance Spectroscopy (MRS)

Neuroinflammation Imaging

We use advanced techniques to study microglial activation

• TSPO PET Imaging
  Visualize microglial activation using radiotracers like PK11195 or PBR28.
• Iron-Sensitive MRI (T2 Mapping)
  Detect iron accumulation as a proxy for neuroinflammatory activity.

Multimodal Imaging Integration

Our expertise includes

• PET/MRI Co-Registration
  Correlate Aβ or tau deposition with structural and functional changes.
• Machine Learning Analysis
  Use AI-driven tools to identify imaging biomarkers and predict disease progression.

Model Validation and Translational Relevance

Our imaging services are tailored to validate AD models and ensure translational relevance

• Transgenic Model Profiling
• Aged Non-Human Primate Studies
• Longitudinal Imaging

Partner with Ace Therapeutics to leverage cutting-edge neuroimaging technologies that illuminate the complexities of Alzheimer's disease. Contact us to design a study tailored to your research goals.

Frequently Asked Questions (FAQ)

Our products and services are for research use only and can not be used for diagnostic or other purposes.