Alzheimer's Disease Preclinical Research Solutions

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Preclinical Assays and Screening Services

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Alzheimer's disease drug discovery demands precise tools to unravel its multifaceted pathology. At Ace Therapeutics, we offer a comprehensive suite of preclinical assays and screening services tailored to identify, validate, and optimize therapeutic candidates. Our expertise spans molecular, cellular, and systems-level analyses, empowering researchers to overcome translational challenges and advance promising AD therapies.

Why Partner with Ace Therapeutics

Alzheimer's research faces unique challenges, including the need to target complex, interconnected pathways while avoiding off-target effects. Our preclinical services address these challenges by offering

Human-relevant models that replicate AD-specific pathology.
High-resolution data to guide structure-activity relationship (SAR) optimization.
Scalable workflows adaptable to small molecules, biologics, and gene therapies.

Comprehensive Assays and Screening Services of Alzheimer's Disease

Biochemical Assays

Quantify target engagement and enzymatic activity at the molecular level.

Amyloid-beta aggregation kinetics monitored via Thioflavin T fluorescence and FRET-based oligomer detection.
Tau phosphorylation assays using phospho-specific antibodies (pTau181, pTau217) and recombinant kinases (GSK-3β, CDK5).
BACE1 and γ-secretase activity screening with fluorogenic substrates and MS-based cleavage product analysis.

Cell-Based Assays

Evaluate compound efficacy and toxicity in physiologically relevant systems.

iPSC-derived neuronal models with APOE4 or familial AD mutations (PSEN1, APP).
3D neurospheroid assays incorporating Aβ plaques, tau tangles, and microglia.
Synaptic function analysis using multi-electrode arrays (MEAs) and calcium imaging.
Autophagy flux measurement in LC3-GFP reporter lines.

Neuroinflammation Assays

Dissect the role of glial cells in AD progression and therapeutic response.

Microglia activation profiling via IBA1/TREM2 immunofluorescence and cytokine multiplex panels (IL-6, TNF-α).
Astrocyte reactivity assays measuring GFAP, C3, and S100β expression.
NLRP3 inflammasome activation monitored by caspase-1 activity and IL-1β release.
Phagocytosis assays quantifying Aβ clearance in iPSC-derived microglia.

Workflow Integration

Our end-to-end workflows ensure seamless data generation and interpretation.

Step 1 Target Identification & Validation

Leverage CRISPR screens or RNAi libraries to pinpoint AD-relevant targets.

Step 2 Mechanistic Profiling

Assess target engagement, enzymatic inhibition, and pathway modulation.

Step 3 Functional & Toxicity Testing

Evaluate compound effects in iPSC-derived neurons, glia, or 3D spheroids.

Step 4 Data Analytics & Reporting

Receive actionable insights, including dose-response curves, IC50 values, and Z'-factor validation.

Partner with Ace Therapeutics to leverage cutting-edge preclinical assays that bridge the gap between discovery and clinic. Contact us to design a study aligned with your Alzheimer's research goals.

Frequently Asked Questions (FAQ)

How quickly can I receive screening results for a compound library?

High-throughput screens typically deliver preliminary data within 2–3 weeks, depending on library size.

Can your BBB models mimic AD-related barrier dysfunction?

Yes. We incorporate Aβ-exposed endothelial cells to simulate leaky BBB phenotypes.

Do you offer custom CRISPR editing for non-AD genes?

Absolutely. Our platform supports editing of any gene linked to neurodegenerative or metabolic pathways.

How do you ensure data reproducibility in mitochondrial assays?

We use standardized cell lines, control for batch effects, and validate findings across multiple replicates.

Are your services compatible with academic and industry budgets?

Yes. We provide scalable solutions with flexible pricing for both sectors.

Our products and services are for research use only and can not be used for diagnostic or other purposes.