Autoimmune Hematologic Disease Models
Ace Therapeutics delivers scientifically rigorous preclinical research services focused on autoimmune hematologic diseases using validated in vivo models. Our specialized platform enables robust evaluation of novel therapeutics targeting immune-mediated blood disorders, from mechanistic studies to efficacy assessments.
Autoimmune hematologic diseases are characterized by the immune system's aberrant targeting of blood components, including red blood cells, white blood cells, and platelets. Common disorders include:
These diseases are complex, often requiring immune modulation strategies. In vivo models that mimic the pathophysiology and clinical features of these disorders are essential for drug candidate validation.
Autoimmune hematologic diseases involve dysregulated immune responses against hematopoietic cells or blood components, leading to conditions such as immune cytopenias, hemolytic disorders, and transplant-related complications. Our models recapitulate key clinical pathologies to support your drug development pipeline.
| Disease Model | Primary Applications | Drug Evaluation Suitability |
| aGVHD Model | T-cell depletion therapies, JAK inhibitors, Treg modulators | mAbs, small molecules, cellular therapies |
| Immune Thrombocytopenia (ITP) | FcRn blockers, TPO mimetics, B-cell targeting | Biologics, peptide therapeutics |
| Autoimmune Hemolytic Anemia (AIHA) | Complement inhibitors, B-cell depletion | Monoclonal antibodies, RNA therapeutics |
| Pure Red Cell Aplasia (PRCA) | Immunomodulators, erythropoiesis stimulators | Small molecules, cytokine modulators |
Ace Therapeutics offers a panel of validated animal models to support mechanistic studies, pharmacokinetics, efficacy testing, and safety profiling of therapeutic agents targeting autoimmune blood disorders.
To ensure scientific rigor and translational relevance, all models undergo continuous validation using:
To learn more about how Ace Therapeutics can support your autoimmune hematologic drug development program, contact our scientific team today. We are ready to assist with study design, model selection, and execution of robust preclinical in vivo studies tailored to your therapeutic strategy.
Do you offer custom autoimmune disease models beyond your listed portfolio?
Yes, we can develop or adapt models upon request, depending on your research needs.
What types of therapeutic agents can be tested in these models?
Our models are suitable for testing biologics (e.g., monoclonal antibodies), small molecules, cytokine modulators, cell therapies, and more.
How do you validate the autoimmune phenotype in each model?
We use multi-parameter approaches including hematologic measurements, histopathology, immune cell phenotyping, and antibody detection.
Can I run a pilot study before committing to a full preclinical program?
Yes, we support small-scale pilot studies to assess feasibility and optimize protocols.
Are humanized mouse models available for immune-based evaluations?
Yes, we can use NSG or other immunodeficient strains engrafted with human PBMCs or hematopoietic stem cells.
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Conclusion
Ace Therapeutics specializes in preclinical research for hematologic diseases, providing reliable models and cutting-edge analytical support to advance therapeutic discovery.
With years of scientific experience, we offer integrated solutions that help biopharma teams turn early-stage ideas into robust preclinical outcomes.