Preclinical Hematology R&D Solutions

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Project Description

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Other Hematologic Models

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Ace Therapeutics provides comprehensive in vivo model-based services to support pharmaceutical and biotechnology clients in the early evaluation of drug candidates for complex blood disorders. Our focus includes models beyond traditional anemia and genetic hematology, such as polycythemia vera, leukocytosis, thrombocytosis, and radiation-induced hematopoietic injury.

Expanded Hematologic Model Portfolio

We deliver disease-specific models beyond standard offerings, each pathologically and pharmacologically characterized for human-translatable insights.

Indication	Model Platform	Key Applications
Polycythemia Vera	JAK2-V617F mutation knock-in mice	Evaluation of erythrocytosis, splenomegaly, marrow fibrosis
Leukocytosis / Thrombocytosis	Cytokine overexpression (GM-CSF, TPO, EPO) via transgenics or vector systems	Assessment of excessive myeloid or platelet lineage expansion
Radiation-Induced Hematopoietic Damage	Whole-body or targeted irradiation	Acute bone marrow failure, immune cell depletion, stem cell repopulation

Model-Specific Highlights and Validation

Polycythemia Vera Model

Key Features: Mimics human PV pathology including elevated RBCs, hypercellular marrow, and splenomegaly.
Validation: Blood counts (RBC, HCT, HGB), bone marrow histology, JAK-STAT pathway activation, spleen weight.
Therapeutic Applications: JAK pathway inhibitors, anti-proliferative agents, epigenetic modulators.

Leukocytosis and Thrombocytosis Models

Key Features: GM-CSF, TPO, or EPO gene overexpression induces selective myeloid or platelet lineage expansion.
Validation: Flow cytometry for granulocytes or megakaryocytes, cytokine profiling, complete blood count, bone marrow smear.
Therapeutic Applications: Myeloproliferative disorder research, anti-inflammatory drugs, hematopoietic regulators.

Radiation-Induced Hematopoietic Injury Models

Key Features: Simulates acute bone marrow failure; commonly used to evaluate radioprotective or regenerative therapies.
Validation: Bone marrow cellularity, peripheral blood cytopenia, survival analysis, colony-forming assays.
Therapeutic Applications: Bone marrow transplant adjuncts, regenerative biologics, anti-radiation agents.

Service Workflow for Hematologic In Vivo Models

We follow a rigorous and customizable preclinical service workflow to ensure scientific robustness and alignment with your therapeutic strategy:

Initial Consultation	Discussion of disease focus and study goals Model selection and endpoint design
Model Preparation	Breeding or induction of disease model Baseline hematologic and physiological characterization
Drug Administration	Route, dosage, and schedule optimization Randomization and control inclusion
Monitoring and In-Life Analysis	Peripheral blood sampling, CBC Body weight, behavior, survival metrics
Endpoint Studies	Bone marrow analysis, histology, flow cytometry Serum cytokine or biomarker assays
Data Reporting	Comprehensive raw data, statistical interpretation Graphical data visualization, scientific discussion

Applications of Our Hematologic In Vivo Services

Candidate Screening

Evaluate therapeutic potential of new agents in physiologically relevant in vivo systems.

Mechanism of Action Studies

Understand cellular targets and signaling pathways involved in hematopoietic modulation.

Biomarker Evaluation

Identify and quantify pharmacodynamic markers in blood, marrow, or spleen.

Toxicity and Safety Profiling

Assess drug-related hematologic toxicity including myelosuppression or immune cell depletion.

If your research involves hematologic conditions such as polycythemia vera, cytokine-driven leukocytosis, or radiation-induced marrow injury, Ace Therapeutics offers deeply characterized in vivo models and CRO expertise to advance your development pipeline. Contact our scientific team for a custom consultation and detailed service proposal.

Frequently Asked Questions (FAQs)

Can models be customized to suit my specific drug mechanism?

Yes. We offer model adjustments such as radiation dose calibration, cytokine levels, or use of immunodeficient strains depending on your study needs.

Do you provide bone marrow transplantation or recovery studies?

Yes. We support marrow transplant setups and longitudinal tracking of hematopoietic recovery using flow cytometry and functional assays.

What types of endpoints can I choose from?

Endpoints include peripheral blood analysis, marrow histopathology, spleen size and cellularity, serum biomarkers, and overall survival.