Obesity Preclinical Contract Research Solutions

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Preclinical Services for Obesity: Gastrointestinal Motility & Nutrient Absorption

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Fig 1. Gastrointestinal motility and nutrient absorption services.

Ace Therapeutics offers comprehensive preclinical services for obesity research, focusing on gastrointestinal motility and nutrient absorption. Our expertise and facilities provide insights into the mechanisms and efficacy of novel therapeutic interventions.

Our services include:

In vivo models of obesity: Diet-induced obesity (DIO) rodent models.
Ex vivo tissue studies: Detailed analyses on isolated gastrointestinal tissues to assess the effects of test compounds on motility.
Gastrointestinal transit assessment: Measurement of gastric emptying, small intestinal transit, and colonic transit.
Evaluation of nutrient absorption: Using metabolic cages and tracer studies to quantify nutrient balance and uptake.

Measurement of gut hormones and related biomarkers: Analysis of circulating hormones and metabolic markers.

Introduction: Addressing the Obesity Epidemic Through Targeted Preclinical Research

Obesity is a significant and escalating global health challenge. It is associated with serious comorbidities, highlighting the urgent need for effective therapeutic interventions. Preclinical research is crucial for developing innovative treatments. The pathophysiology of obesity is complex, involving the gut-neuroendocrine interplay. Targeted approaches focusing on specific physiological processes are essential for successful therapeutic strategies. Gastrointestinal motility and nutrient absorption are critical factors in obesity. Understanding their alterations in obese individuals is essential for devising effective interventions.

Fig 2. Micronutrient deficiencies in obesity. Fig.1. Micronutrient deficiencies in obesity and after bariatric surgery, risks and management. (Gasmi, A., et al. 2022)

Exploring Promising Therapeutic Targets in Preclinical Development

Ace Therapeutics offers expert preclinical CRO services for obesity research, specializing in gastrointestinal motility and nutrient absorption. Our expertise and comprehensive methodologies can accelerate your drug development program.

Therapeutic Target	Mechanism of Action (GI Focus)	Potential Preclinical Study Focus at Ace Therapeutics
GLP-1 Receptor Agonists	Inhibit gastric emptying, may influence intestinal motility, enhance satiety signals.	Evaluating the effects of novel GLP-1 agonists on gastric emptying rates and intestinal transit times in DIO rodent models. Assessing the impact on food intake and body weight.
CCK1 Agonists	Regulate gastric emptying and intestinal motility, promote satiety.	Investigating the effects of CCK1 agonists on gastrointestinal motility patterns and nutrient absorption in obese animal models. Assessing their impact on satiety biomarkers.
CB1 Antagonists	Modulate gastrointestinal motility, potentially reduce nutrient absorption.	Evaluating the effects of CB1 antagonists on gastric emptying and intestinal transit in obese models. Assessing potential impact on appetite and metabolic parameters.
Electrical Stimulation	Directly influences gastric motility patterns.	Preclinical studies to optimize electrical stimulation parameters for modulating gastric emptying in obese animal models. Assessing the impact on food intake.
Gut Microbiota Targeting	Modulates gut microbial composition, potentially affecting nutrient extraction and gut hormones.	Investigating the effects of prebiotics or probiotics on gut microbiota composition and their subsequent impact on gastrointestinal motility and nutrient absorption in obese models.

Comprehensive Preclinical Methodologies for Accurate Assessment

Ace Therapeutics utilizes a range of established and cutting-edge preclinical techniques to provide accurate and reliable assessments of gastrointestinal motility and nutrient absorption.

Assessments	Parameter Assessed	Preclinical Method/Technique
Gastrointestinal Motility Assessment	Gastric Emptying	Scintigraphy
		Wireless Motility Capsule
		Analysis of Gastric Contents
	Small Intestinal Transit	Scintigraphy
	Small Intestinal Transit	Wireless Motility Capsule
	Colonic Transit	Scintigraphy
	Colonic Transit	Wireless Motility Capsule
	Gastrointestinal Contractility	Manometry
	Ex Vivo Motility	Organ Bath Studies
Nutrient Absorption Assessment	Overall Absorption	Metabolic Cages
	Specific Nutrients	Tracer Studies
	Protein Absorption	Pulse Feeding Assays
	Various Nutrients	Biomarker Analysis (ELISA, HPLC, mass spectrometry, atomic absorption spectrometry)

Translating Preclinical Insights into Potential Obesity Therapeutics

Preclinical research on gastrointestinal motility and nutrient absorption is vital for developing novel obesity therapies. These studies help to:

Identify and validate new drug targets.
Evaluate the efficacy and safety of drug candidates.
Elucidate mechanisms of action.
Optimize dosing regimens and treatment strategies.

Reference

Gasmi, A., et al. (2022). Micronutrients deficiences in patients after bariatric surgery. European journal of nutrition, 61(1), 55-67.