Key Pathological Features
These models reproduce hallmark features of gastric ulceration, such as disruption of the surface epithelium, loss of glandular architecture, mucosal hemorrhage, neutrophil and macrophage infiltration, increased lipid peroxidation, reduced gastric mucus production, and decreased prostaglandin E2 levels.
Preclinical Research Applications
In drug discovery, gastric ulcer models are widely employed to screen cytoprotective agents, antisecretory drugs, mucosal defense enhancers, and natural product extracts with antioxidant or anti-inflammatory properties. They also facilitate mechanistic studies on pathways involving nitric oxide, heat shock proteins, cyclooxygenase isoforms, and the gut microbiota’s role in ulcer healing.
Ace Therapeutics provides customized research solutions based on alcoholic liver disease models.
Ace Therapeutics provides customized research solutions based on irritable bowel syndrome models.
Ace Therapeutics specializes in preclinical gastroenterology and hepatology research. With expertise in disease model customization, pathology research, drug development, and more, we offer comprehensive solutions to advance scientific discoveries.