Ace Therapeutics
Animal Models of Metabolic Associated Steatohepatitis (MASH)
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Animal Models of Metabolic Associated Steatohepatitis (MASH)

Animal models of metabolic associated steatohepatitis (MASH), previously known as non‑alcoholic steatohepatitis (NASH), are experimental systems that recapitulate key features of human MASH, including hepatic steatosis, lobular inflammation, hepatocellular ballooning, and variable degrees of fibrosis.

Application of Animal Models of MASH

In preclinical research, animal models of MASH are applied in several key areas. They enable mechanistic studies of hepatic lipotoxicity, oxidative stress, inflammasome activation, and fibrogenesis pathways. These models serve as platforms for evaluating novel pharmacotherapies, including thyroid hormone receptor‑β agonists, FXR agonists, GLP‑1 receptor agonists, and dual or triple incretin agonists.

  • Development and Evaluation of Hepatoprotective Drugs
  • Drug Hepatotoxicity Risk Assessment
  • Research on the Dynamic Process of Liver Fibrosis