Application of Animal Models of MASH
In preclinical research, animal models of MASH are applied in several key areas. They enable mechanistic studies of hepatic lipotoxicity, oxidative stress, inflammasome activation, and fibrogenesis pathways. These models serve as platforms for evaluating novel pharmacotherapies, including thyroid hormone receptor‑β agonists, FXR agonists, GLP‑1 receptor agonists, and dual or triple incretin agonists.