ABT-546

Product Details
Formula	C30H48N2O6
Molecular Weight	532.71
Smiles String	O=C([[email protected]]1[[email protected]](CC(C)(C)CCC)N(CC(N(CCCC)CCCC)=O)C[[email protected]@H]1C2=CC(OC)=C(OCO3)C3=C2)O

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

ABT-546 (A-216546) is a potent, highly selective and active endothelin ETA receptor antagonist with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned human endothelin ETA. ABT-546 is >25,000-fold more selective for the ETA receptor than for the ETB receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50 of 0.59 nM and 3 nM, respectively.

! For research use only. Not intended for any clinical use.