Biospecimen Collection and Analysis Services for Cardiovascular Disease Research

At Ace Therapeutics, we aim to provide comprehensive cardiovascular biospecimen collection and analysis services. Our expert team assists researchers in acquiring diverse and high-quality biospecimens to meet the demands of cardiovascular disease research.

The Importance of Biospecimen for Cardiovascular Research

Cardiovascular disease research utilizes diverse biospecimens, including animal heart and vascular tissues, blood, and various body fluids, selected based on specific research objectives and study designs. Acquiring high-quality biospecimens is a critical foundational step in cardiovascular research, and where appropriate sample preparation techniques are essential for generating reliable downstream data, however this process often presents substantial technical challenges.

Fig. 1 Summary schematic of biospecimen and omics analyses. (Fields AJ, et al., 2023)

Ace Therapeutics provide custom biospecimen collection and analysis services for cardiovascular disease research. Adhering to standardized experimental procedures, we collect and process biospecimens to ensure consistency and precision throughout the study.

Custom Biospecimen Collection Services

We implement standardized biospecimen collection protocols for cardiovascular research, ensuring sample integrity for reproducible discoveries.

Biospecimen Analysis Services
We provide end-to-end biospecimen analysis services from biomarker quantification to multi-omics with high data quality.

• Biomarker Testing and Analysis
  We conduct a suite of biomarker assays on biospecimens to evaluate the pathophysiological status of the cardiovascular system in animal models.
  Inflammation Biomarker Testing: Detecting biomarkers reflecting inflammatory status, such as tumor necrosis factor-α-induced protein 3 (TNFAIP3) and C-reactive protein (CRP).
  Cardiac Injury Biomarker Testing: Myocardial injury is assessed via immunoassays for established biomarkers, including cardiac troponin I/T (cTnI/T) and creatine kinase MB isoenzyme (CK-MB).
• Multi-Omics Solutions for Cardiovascular Research
  We employ multi-omics approaches to analyze biospecimens, uncovering the molecular mechanisms underlying cardiovascular diseases from a systems biology perspective.
  Genomics: Applying genome-wide association studies (GWAS) to identify genetic variants associated with cardiovascular disease.
  Transcriptomics: Analyzing changes in cardiovascular disease-related gene expression across different pathological states.
  Proteomics: Identifying and quantifying proteins, discovering biomarkers, and investigating protein-protein interactions and post-translational modifications.
  Metabolomics: Analyzing metabolite variations in biospecimens to elucidate metabolic processes.
• Professional Pathology Research
  Histopathological analysis enables clear visualization of structural alterations and pathological characteristics within cardiovascular tissues.
  H&E Staining: Observing the basic tissue structure and cellular morphology of the cardiovascular system.
  Masson's Trichrome Staining: Assessing the severity of collagen deposition and fibrosis.
  Oil Red O Staining: Detecting lipid deposition in tissues.
  Immunohistochemistry (IHC): Detecting specific protein expression (e.g., FAP for fibrosis detection).
• Advanced Cardiovascular Imaging Services
  We can utilize imaging techniques to non-invasively assess the structure and function of the cardiovascular system in real time, along with functional and physiological testing.
  Hemodynamic Monitoring: Measuring parameters such as blood pressure, cardiac output, and vascular resistance using Doppler ultrasound.
  Electrocardiogram (ECG) Monitoring: Evaluating cardiac electrophysiological activity to detect arrhythmias and ischemic events.
  CT Imaging: Analyzing coronary plaque formation in experimental animals via CT imaging.

Ace Therapeutics is a leading contract research organization specializing in cardiovascular disease research. We provide high-quality biospecimen collection and analysis services, ensuring the accuracy, reliability, and reproducibility of your downstream experiments. If you are interested in our services, please do not hesitate to contact us.

1. Fields, A.J.; et al. Protocol for Biospecimen Collection and Analysis Within the BACPAC Research Program. Pain Med. 2023, 24(Suppl 1): S71-S80.