Brochures

Ace Therapeutics in Cardiovascular Disease Research

Ace Therapeutics is a contract research organization focused on advancing cardiovascular therapeutics through integrated discovery and development solutions.

Familial Hypercholesterolemia Models

Familial hypercholesterolemia (FH) is an autosomal dominant disorder marked by severely elevated plasma LDL‑cholesterol, premature atherosclerosis, and increased cardiovascular risk.

FeCl₃-induced Thrombosis Models

FeCl₃‑induced thrombosis model is a widely used, highly reproducible preclinical assay for acute arterial or venous thrombus formation.

Hypertrophic Cardiomyopathy Models

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder, characterized by left ventricular hypertrophy, myocyte disarray, interstitial fibrosis, and diastolic dysfunction.

Cardiac Organoid Models

Cardiac organoids are self assembling, three dimensional multicellular constructs derived from human induced pluripotent stem cells (iPSCs).

Myocardial Infraction Models

Left anterior descending (LAD) coronary artery ligation model is the gold‑standard surgical platform for inducing ischemic myocardial infarction (MI) in rodents, rabbits, and large animals.

Transverse Aortic Constriction (TAC) Models

Transverse aortic constriction (TAC) model is the preeminent surgical platform for inducing pressure overload‑induced left ventricular hypertrophy and subsequent heart failure (HF) in rodents.

hiPSC–derived Cardiomyocytes

Human induced pluripotent stem cell‑derived cardiomyocytes (hiPSC‑CMs) represent a transformative, patient‑relevant platform that bridges the gap between immortalized cell lines and animal models.

Cardiovascular In Vitro & Ex Vivo Platforms

Cardiovascular in vitro and ex vivo platforms address critical gaps in target validation, lead compound prioritization, safety pharmacology, and mechanism‑of‑action studies.

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Ace Therapeutics in Cardiovascular Disease Research

Familial Hypercholesterolemia Models

FeCl3-induced Thrombosis Models

Hypertrophic Cardiomyopathy Models

Cardiac Organoid Models

Myocardial Infraction Models

Transverse Aortic Constriction (TAC) Models

hiPSC–derived Cardiomyocytes

Cardiovascular In Vitro & Ex Vivo Platforms

FeCl₃-induced Thrombosis Models