Transverse Aortic Constriction (TAC) Models

The transverse aortic constriction (TAC) model is the preeminent surgical platform for inducing pressure overload‑induced left ventricular (LV) hypertrophy and subsequent heart failure (HF) in rodents. TAC model imposes a fixed, afterload‑dependent hemodynamic burden that closely recapitulates the clinical progression of hypertensive heart disease and aortic stenosis.

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Brochure - Transverse Aortic Constriction (TAC) Models

Our Services for TAC Models

Comprehensive Hemodynamic Phenotyping
Serial transthoracic echocardiography is performed to assess key structural and functional parameters, including IVSd, LVPWd, LV mass index, relative wall thickness (RWT), EF, FS, E/A ratio, and E/e' ratio, enabling longitudinal tracking of concentric remodeling and diastolic progression.
Hypertrophy & Fibrosis Quantitation
Histomorphometric analysis using Wheat Germ Agglutinin (WGA) or laminin staining for quantitative assessment of myocyte cross‑sectional area, with complementary evaluation of interstitial fibrosis available upon request.
Therapeutic Efficacy & Dose‑finding
Evaluation of standard‑of‑care agents (ACE inhibitors, ARBs, β‑blockers, and mineralocorticoid receptor antagonists) alongside emerging therapeutic classes, including myosin inhibitors, SGLT2 inhibitors, anti‑inflammatory biologics, and gene‑silencing modalities (ASOs, siRNAs, and LNP‑formulated mRNA).

Transverse Aortic Constriction (TAC) Models

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Transverse Aortic Constriction (TAC) Models

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