Hyperlipoproteinemia & Atherosclerosis Animal Models
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Hyperlipoproteinemia & Atherosclerosis Animal Models

Well-established animal models of hyperlipoproteinemia and atherosclerosis serve as indispensable tools for investigating cardiovascular disease pathogenesis, evaluating drug candidates, and developing novel therapeutic interventions. These models faithfully recapitulate key aspects of dyslipidemia and atherosclerotic plaque progression, providing critical insights for translational medicine.

Our validated preclinical platform employs genetically engineered murine models, including ApoE-/- and LDLR-/- knockout strains, that accurately recapitulate human cardiovascular pathophysiology to generate translational data for therapeutic development. These well-characterized models undergo comprehensive phenotypic characterization under controlled dietary regimens, enabling precise evaluation of candidate compounds' effects on atherogenesis, plaque stability, and systemic lipid metabolism with high clinical relevance.

Genetic Modification Models

  • ApoE KO Mice
  • LDLR KO Mice
  • hPCSK9 Mice

Preclinical Services

  • Hyperlipoproteinemia & Atherosclerosis Drug Development Services
  • Hyperlipoproteinemia & Atherosclerosis Pathogenesis Research Services
  • Preclinical Efficacy Evaluation for Anti-Hyperlipoproteinemia/Atherosclerosis Drugs