Myocardial Infraction Models

The left anterior descending (LAD) coronary artery ligation model is the gold‑standard surgical platform for inducing ischemic myocardial infarction (MI) in rodents, rabbits, and large animals. By performing a permanent or transient (ischemia‑reperfusion, I/R) occlusion of the LAD at a defined anatomical branch point, this procedure generates a reproducible, transmural infarct zone that closely mimics clinical ST‑segment elevation MI.

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Our Services for Myocardial Infarction Models

Hemodynamic & Functional Characterization
Comprehensive cardiac performance assessment utilizing high‑resolution transthoracic echocardiography (with parameters including EF, FS, LVEDD, LVESD, and wall motion score index), invasive pressure‑volume loop analysis, and telemetric hemodynamic monitoring for continuous recording of blood pressure and heart rate trends.
Infarct Sizing & Tissue Viability
Quantitative area‑at‑risk (AAR) and infarct size assessment is performed via TTC/Evans blue double staining, with normalization to left ventricular mass. Histological evaluation using Masson's trichrome, picrosirius red, and wheat germ agglutinin (WGA) enables comprehensive tissue characterization, including fibrosis fraction, myocyte cross‑sectional area, and transmural scar thickness mapping.
Ischemia‑Reperfusion (I/R) Studies
Customizable occlusion and reperfusion protocols designed to evaluate reperfusion injury, oxidative stress, and mitochondrial permeability transition pore (mPTP) opening.

Myocardial Infraction Models

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Myocardial Infraction Models

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