Familial Hypercholesterolemia Models

Familial hypercholesterolemia (FH) is an autosomal dominant disorder marked by severely elevated plasma LDL‑cholesterol, premature atherosclerosis, and increased cardiovascular risk. Preclinical models that recapitulate the human LDL‑receptor dysfunction are indispensable for dissecting disease mechanisms, evaluating lipid‑lowering therapeutics.

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Brochure - Familial Hypercholesterolemia Models

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LDLR KO Mouse Model
These mice exhibit a 2- to 3-fold increase in total and LDL cholesterol on a normal chow diet, with exacerbated hyperlipidemia and pronounced aortic root lesions when fed a high-fat, high-cholesterol Western diet. The model faithfully mimics the hepatic clearance defect seen in heterozygous and homozygous FH patients.
APOE KO Mouse Model
On a normal diet, these animals develop severe spontaneous hypercholesterolemia and complex, calcified, rupture-prone atherosclerotic plaques throughout the aorta, closely resembling human advanced FH-related cardiovascular pathology. The model is independent of dietary manipulation, offering a consistent baseline for long-term studies.

Familial Hypercholesterolemia Models

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Familial Hypercholesterolemia Models

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