FeCl3-induced Thrombosis Models

FeCl₃-induced Thrombosis Models

FeCl₃ ‑ induced thrombosis model is a widely used, highly reproducible preclinical assay for acute arterial or venous thrombus formation. This model enables precise spatiotemporal control of injury severity, quantitative endpoint measurements (e.g., time to occlusion, thrombus weight, and histomorphometry), and is amenable to both murine and larger animal species.

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Brochure - FeCl3-induced Thrombosis Models

Key Application Areas

Combination Therapy Optimization
Synergistic or antagonistic interactions between antiplatelets, anticoagulants, and anti‑inflammatory agents
Device‑related Thrombosis
Evaluation of drug‑eluting stents, coated vascular grafts, and catheter materials in a hypercoagulable milieu
Genetic or Pharmacological Modulation of Coagulation Factors
Knockdown/overexpression of FVIII, FIX, or tissue factor pathway inhibitor (TFPI)
Translational Biomarker Discovery
Correlation of plasma thrombin‑antithrombin (TAT) complexes, D‑dimer, and platelet‑derived microparticles with thrombus burden and treatment response

FeCl3-induced Thrombosis Models

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FeCl3-induced Thrombosis Models

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FeCl₃-induced Thrombosis Models

FeCl₃-induced Thrombosis Models