hiPSC–derived Cardiomyocytes

Human induced pluripotent stem cell‑derived cardiomyocytes (hiPSC‑CMs) represent a transformative, patient‑relevant platform that bridges the gap between immortalized cell lines and animal models. hiPSC‑CMs recapitulate the genetic background, ion channel repertoire, sarcomeric architecture, and metabolic phenotype of the donor, enabling the study of cardiovascular diseases in a truly human context.

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Our Services with hiPSC‑Derived Cardiomyocytes

Comprehensive Cardiotoxicity Profiling
Multi‑parametric assessment of drug‑induced proarrhythmic risk, incorporating multi‑electrode array (MEA) recordings for field potential duration (FPD) and QT interval analysis, patch‑clamp electrophysiology for hERG and other ion channel characterization, and high‑speed video microscopy for contractility and beat‑to‑beat irregularity monitoring.
High‑Throughput Screening (HTS) & Lead Optimization
Available in 384‑well format, compatible with automated imaging and MEA platforms, enabling rapid screening of compound libraries for inotropic, anti‑arrhythmic, or cardioprotective activity. Customizable endpoint panels include mitochondrial membrane potential, reactive oxygen species (ROS) production, and apoptosis/necrosis detection.
Contractility & Calcium Transient Assays
Label‑free, real‑time measurements of beat amplitude, contraction velocity, relaxation kinetics, and beat‑to‑beat variability using impedance‑based systems or optical flow methodologies. Simultaneous calcium transient recording provides comprehensive excitation‑contraction coupling readouts.

hiPSC–derived Cardiomyocytes

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hiPSC–derived Cardiomyocytes

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