Animal Models of Aortic Dissection

Aortic dissection is a life‑threatening condition characterized by an intimal tear and propagation of a false lumen within the medial layer. Our models recapitulate key human pathological features, through established approaches such as chronic angiotensin II infusion in ApoE‑deficient mice, BAPN administration to impair elastin cross‑linking, or localized surgical disruption of the aortic wall.

Download

Key Preclinical Application Areas

Antihypertensive and Hemodynamic Modulation: Screening of β‑blockers, ARBs, ACE inhibitors, and calcium channel blockers for their capacity to reduce wall stress and prevent dissection progression or rupture; assessment of dose‑dependent efficacy and pulse‑pressure modulation.
Matrix Metalloproteinase (MMP) and Protease Inhibition: Evaluation of broad‑spectrum or selective MMP inhibitors and serine protease blockers targeting elastase and cathepsin activity to preserve medial integrity.
Anti‑inflammatory and Immunomodulatory Therapies: Testing of IL‑1β, TNF‑α, or IL‑6 pathway blockers, corticosteroids, and macrophage‑modulating agents to attenuate perivascular inflammation and subsequent extracellular matrix degradation.
Smooth Muscle Cell (SMC) Preservation and Reparative Strategies: Assessment of growth factors (TGF‑β, PDGF), Rho‑kinase inhibitors, or SMC‑specific gene therapies aimed at maintaining contractile phenotype and restoring medial resilience.

Animal Models of Aortic Dissection

Fill In This Form to Get Details of Our Case Studies.

Animal Models of Aortic Dissection

You might be interested in...