AP14145 hydrochloride

Product Details
Formula	C18H18ClF3N4O
Molecular Weight	398.81
Smiles String	CC(NC1=C2C(N=C(N[[email protected]@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O.[H]Cl

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF).

! For research use only. Not intended for any clinical use.