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Avatrombopag-d8 hydrochloride

Cat. No: CDIA-2237

Synonyms: AKR-501-d8 (hydrochloride); E5501-d8 (hydrochloride); YM477-d8 (hydrochloride)

Size: 500 mg

Price: Inquiry

Product Details
Formula	C29H27D8Cl3N6O3S2
Molecular Weight	694.16
Smiles String	O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5C([2H])([2H])C([2H])([2H])N(C6CCCCC6)C([2H])([2H])C5([2H])[2H])S3)=O)C=C2Cl)CC1)O.Cl

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

Description

Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.

! For research use only. Not intended for any clinical use.