Animal Models of Arrhythmia

Animal models of arrhythmia are experimental systems that reproduce abnormal cardiac electrical activity, including atrial and ventricular tachyarrhythmias, bradyarrhythmias, and conduction disorders. These models are indispensable for investigating the cellular and molecular mechanisms of arrhythmogenesis.

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Based on clinical manifestations and electrophysiological characteristics, these models are broadly classified into two main categories: bradyarrhythmia models and tachyarrhythmia models. In addition, some specialized models have been developed to study specific conditions such as atrial fibrillation and conduction block.

Bradyarrhythmia Models

Drug-induced Models (Propranolol, Acetylcholine)
Surgically-induced Models (Atrioventricular node ablation or blockade)

Tachyarrhythmia Models

Drug-induced Models (Barium chloride, Calcium chloride, Cardiac glycosides)
Surgically-induced Models (Myocardial ischemia/reperfusion)

Atrial Fibrillation Models

Electrical Stimulation-induced Models
Drug-induced Models (Aconitine, Acetylcholine)

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Animal Models of Arrhythmia

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