Animal Models of Hypertrophic Cardiomyopathy

As research into hypertrophic cardiomyopathy (HCM) advances, the need for physiologically relevant animal models has become increasingly critical. Ace Therapeutics is committed to the forefront of cardiovascular disease research, offering a diverse portfolio of validated HCM animal models.

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Myocardial hypertrophy models are established through two principal approaches. One induces pathological hypertrophy by increasing cardiac afterload to mimic conditions such as hypertension or aortic stenosis, ultimately progressing to heart failure. The other replicates hereditary cardiomyopathy or chronic stress states via genetic modifications or pharmacological manipulation of neuroendocrine pathways.

Transgenic Models of Hypertrophic Cardiomyopathy (Mybpc3-KO / Myh6-R404Q)

For sarcomere dysfunction studies
In hypertrophic cardiomyopathy phenotypic diversity research
For small-molecule target validation

ISO-induced Hypertrophic Cardiomyopathy Models

For neuroendocrine mechanism studies
For evaluating antioxidant and anti-apoptotic therapies

TAC-induced Hypertrophic Cardiomyopathy Models

For pressure overload signaling studies
For cardiac remodeling and fibrosis research
For anti-fibrotic and antihypertensive drug evaluation

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Animal Models of Hypertrophic Cardiomyopathy

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