Darusentan

Product Details
Formula	C22H22N2O6
Molecular Weight	410.42
Appearance	Solid
Purity	98.67%
Smiles String	COC1=NC(O[[email protected]](C(O)=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)=NC(OC)=C1

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM.

! For research use only. Not intended for any clinical use.