Guanfu base A

Product Details
Formula	C24H31NO6
Molecular Weight	429.51
Appearance	Solid
Purity	≥98.0%
Smiles String	O[[email protected]@]12C3[[email protected]]45[[email protected]@]([[email protected]@H]6O)([H])C1(CC([[email protected]@]6([H])[[email protected]]2OC(C)=O)=C)C[[email protected]@]7([H])[[email protected]]4([H])[[email protected]@](C)(C[[email protected]](OC(C)=O)C5)C[[email protected]]37

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, sealed storage, away from moisture and light *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light)

Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes. Guanfu base A also inhibits HERG channel current.

! For research use only. Not intended for any clinical use.