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Losartan carboxylic acid

Cat. No: CDIA-0582

CAS. No.: 124750-92-1

Synonyms: E-3174; EXP-3174

Size: 5 mg

Price: Inquiry

Product Details
Formula	C22H21ClN6O2
Molecular Weight	436.89
Appearance	Solid
Purity	99.35%
Smiles String	O=C(C1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Description

Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

! For research use only. Not intended for any clinical use.