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Myh6-R404Q

Cat. No: CDM0110

Nomenclature: C57BL/6J-Myh6^{em1Cin (R404Q)}

Strain State: Embryo cryopreservation

Gene Summary
Human Ortholog	MYH6
MGI ID	97255
Gene ID	4624
Target Name	Myh6
Synonyms	Myhc, alph, Myhc-, Myhca, Myhc-a, AA517445, alphaMHC, alpha-MHC, A830009F23Rik

Model Description
Description	These mice carry a R404Q missense mutation in Myh6, which attenuates the binding affinity between the myosin heavy chain and cardiac myosin-binding protein C, thereby recapitulating the pathophysiology of human hypertrophic cardiomyopathy.
Disease Connection	Myocardial Hypertrophy, Heart Failure
Phenotype(s)	8210457

! For research use only. Not intended for any clinical use.