TRV-120027 TFA

Product Details
Formula	C45H68F3N13O12
Molecular Weight	1040.10
Appearance	Solid
Purity	98.34%
Sequence	{Sar}-Arg-Val-Tyr-Ile-His-Pro-Ala
Sequence Shortening	{Sar}-RVYIHPA

Storage & Handling
Shipping	Room temperature.
Storage	Sealed storage, away from moisture and light *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light)
Storage Powder	-80 °C/2 years, -20 °C/1 year

TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment.

! For research use only. Not intended for any clinical use.