Spontaneous Models of Diabetes Mellitus

Spontaneous Models of Diabetes Mellitus

Ace Therapeutics offers a variety of spontaneous diabetic animal models with a focus on physiological relevance, predictive validity, and ethical considerations.

Overview of Spontaneous Diabetic Animal Models

Developing spontaneous diabetic animal models involves selecting species of animals that naturally develop diabetes. These models can be identified through extensive breeding programs and careful phenotypic screening. Our rigorous selection process ensures the development of reliable and reproducible models.

Advantages of Spontaneous Diabetes Models
  • Physiological Relevance
These models closely mimic the natural onset and progression of diabetes in humans.
  • Stabilized Diabetic Onset and Progression
The relatively stable process of diabetes onset and progression in spontaneous animal models can better reflect and the natural course of the disease.
  • Ethical Considerations
Spontaneous models often align better with ethical standards, as they do not involve chemical or surgical treatments.

Our Spontaneous Diabetes Animal Models

Ace Therapeutics offers comprehensive range of spontaneous models including spontaneous models of type 1 diabetes mellitus (T1DM), spontaneous models of type 2 diabetes mellitus (T2DM), spontaneous models of gestational diabetes mellitus (GDM), and spontaneous models of diabetic complications

Spontaneous Models of T1DM

Ace Therapeutics offers custom development services for spontaneous models of T1DM, tailored to your specific research needs. Our models are available for studying the autoimmune aspects of T1DM and testing immunomodulatory therapies. Our models including

  • Non-Obese Diabetic (NOD) Mouse
  • Diabetes-Prone BB (BBDP) Rat
  • LETL Diabetic Rat
  • IDDM (LEW.1AR1/Ztm-iddm) Rat

Spontaneous Models of T2DM

We provide custom development of spontaneous models of T2DM across different species. These models are designed to study the metabolic mechanisms of type 2 diabetes and evaluate glucose-lowering drugs.

  • Ob/Ob Mouse
  • Db/Db Mouse
  • Zucker Diabetic Fatty (ZDF) Rat
  • GK (Goto-Kakisaki) Rat
  • NSY (Nagoya-Shibata-Yasuda) Mouse
  • Psammonys Obesus

Spontaneous Models of GDM

Ace Therapeutics offers custom development services of spontaneous models for GDM. Our model development services help to understand the pathogenesis of gestational diabetes mellitus and evaluate the safety and efficacy of therapeutic agents for GDM.

  • Pregnant ZDF Rat

Spontaneous Models of Diabetic Complications

We also provide custom development services of spontaneous models for diabetic complications, such as nephropathy, neuropathy, and retinopathy.

  • GK (Goto-Kakisaki) Rat
  • Zucker Diabetic Fatty (ZDF) Rat
  • NSY (Nagoya-Shibata-Yasuda) Mouse
  • OLETF (Otsuka Long-Evans Tokushima Fatty) Rat

Comprehensive Services for Diabetes Mellitus Research

We provide one-stop service for spontaneous models of diabetes. Our services include evaluation of diabetes-related parameters and cellular biomarkers, specific bioassays, organ sampling, pharmacokinetic studies using rodent metabolic cages, as well as customized research solutions tailored to your needs!

  • HbA1c Measurement
  • Lipid Profile Analysis
  • Retinal Imaging
  • Insulin Tolerance Tests
  • Electrophysiological Tests
  • Glucose Tolerance Tests
  • Urinary Albumin Excretion for Nephropathy Studies
  • Serum Insulin and C-peptide Levels
  • Histopathological Analysis of Pancreatic Islets
  • Customized Tests

For additional information about how our services can be customized to meet your exact needs, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.

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