T2DM is a progressive condition, and to prevent long-term complications, improving and sustaining glycemic control is vital. Despite the variety of available glucose-lowering agents, emphasizing the need for further therapeutic options. Ace Therapeutics provides a complete set of oral antidiabetics development service for T2DM.
Common hypoglycemic drugs include insulin and its analogues, sulfonylurea secretagogues, metformin, α-Glucosidase inhibitor, thiazolidinedione derivative sensitizer, GLP-1 receptor agonist, DPP-4 enzyme inhibitor, etc. Oral antidiabetics help patients to manage themselves more conveniently, and the combination of oral hypoglycemic drugs and insulin can avoid hypoglycemia caused by some oral antidiabetics or insulin overdose.
Insulin analogue formulations with duration of action (Chatterjee, S.; et al. The lancet, 2017)
After oral administration, insulin is absorbed by the hepatic portal vein and transported to the liver, which can activate normal physiological functions. However, the gastrointestinal tract has multiple absorption barriers, such as chemical barriers, enzymatic barriers, and osmotic barriers, making it difficult to achieve ideal oral bioavailability. In order to improve the bioavailability of drugs, many new carriers are applied to drug delivery systems.
With years of experience in drug development, Ace Therapeutics can provide our clients with oral antidiabetics development services that significantly improve the quality of new drugs while accelerating the therapeutic development and drug discovery process. Our services include but not limited to the followings.
Discovering Oral Hypoglycemic for T2DM
Developing Inhibitors and Activators for Related Targets
Designing and Developing Drug Delivery System
Highly Customizable
One-stop Services
High Quality
Professional Team
With years of translational research and drug discovery experience, Ace Therapeutics can accelerate the therapeutic development and drug discovery process about T2DM for our clients worldwide. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.