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Important biomarkers of the vascular system are associated with endothelial dysfunction, inflammatory and coagulation processes, and oxidative stress in diabetes. Ace Therapeutics provides diabetes-associated vascular function biomarker development services aimed at unearthing biomarkers strongly associated with diabetic vascular function in order to support our clients' research in the field of diabetes.
Cardiovascular complications are the leading cause of death in the diabetic population. Persistent hyperglycaemia leads to systemic vascular damage and a range of vascular complications such as atherosclerosis and microangiopathy. Studies have shown that proatherogenic adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and soluble E selectin) and inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α) were elevated in type 2 diabetes mellitus. Therefore, identification and validation of diabetes-related biomarkers of vascular function could help to diagnose diabetic vascular disease more accurately and facilitate the development of novel drugs.
Fig. 1 Schematic overview of panvasculopathy in diabetes mellitus. (Li, Y.; et al., 2023)
Common diabetes-related vascular biomarkers include:
Ace Therapeutics' biomarker and translational research platform provides a flexible strategy from biomarker discovery to validation and fit-for-purpose to fuel translational research on antidiabetic drugs.
We combine multi-omics techniques with bioinformatics tools to help our clients discover biomarkers related to vascular function in diabetes. These biomarkers typically include advanced glycosylation end products and their receptors, adhesion molecules, pro- and anti-inflammatory cytokines, enzymes such as N-acetyl-β-D-glucosaminidase (NAG), and growth factors.
We provide customized biomarker validation strategies through cellular and animal models. Our bioanalytical and biomarker laboratories support method development and validation strategies with a wide range of cutting-edge technologies and state-of-the-art equipment and solutions.
Ace Therapeutics is committed to screening out potential biomarkers from complex data. Then, it strictly verifies the specificity, sensitivity and accuracy of these biomarkers and uses large - scale clinical samples to ensure their reliability. Please contact us for more details.
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
