Toxicokinetic studies of antidiabetic drugs include the study of the extent and duration of systemic exposure to antidiabetic drugs at different dose levels and the determination of toxicokinetic parameters. Ace Therapeutics provides expert toxicokinetic analysis services to help our clients obtain safe, effective drug candidates in antidiabetic drug development.

Why are Toxicokinetic Studies of Antidiabetic Drugs Necessary?

Toxicokinetic studies are an essential component of the preclinical safety assessment of antidiabetic drugs. Their primary value in this process is reflected in the following aspects.

• Assessing the relationship between the in vivo toxic dose of the tested antidiabetic drugs and their associated.
• Assessing the toxic response of the tested antidiabetic drugs and/or their metabolites in different animal species, sexes, ages, and physiological states (e.g., gestational state).
• Providing safety insights and predictive data for subsequent clinical safety evaluations, including starting dose, safety range evaluation, including determining the starting dose and assessing the safety range.

Our Toxicokinetics Study Services for Antidiabetic Drugs

Our comprehensive toxicokinetic studies service involves administering antidiabetic drugs to animals at scheduled intervals and subsequently collecting blood or other biological samples for analysis. These samples are then assayed to generate the resulting toxicokinetic parameters. Here are the key services we provide in the process.

• Test animal selection

We ensure the appropriate selection of animal models and dose groups to estimate whole-body exposure. The animal species we work with include:

• Rodents (rats, mice, guinea pigs)
• Non-rodents (rabbits, miniature pigs, non-human primates)
• Dose design

Dosage settings for toxicity studies are mainly based on toxicological findings and pharmacodynamic responses of the test animals, including the dose, route of administration, choice of animal species, and frequency and periodicity of administration.

• Route of administration

Oral administration, intravenous injection, intramuscular injection, subcutaneous injection, intraperitoneal injection, and others.

• Sample collection
• Serial or terminal sampling
• Blood plasma or serum
• Microsampling
• Tissues or biological fluids sampling

Advantages of Our Toxicokinetics Study Services for Antidiabetic Drugs

• We tailor efficient toxicokinetic analyses to the specific needs of our clients.
• We provide accurate toxicokinetic parameters to our clients by using high-resolution LC-MS/MS analyzers and validated pharmacokinetic software.
• We provide complete toxicokinetic analysis reports, including assessment of toxicokinetic results, interpretation of toxic reactions, and analytical method reports for the tested antidiabetic drugs.

Ace Therapeutics provides toxicokinetic analysis studies for your antidiabetic drug development program to guide informed dosage selection and safety assessment. Please do not hesitate to contact us for further information. Our experts will discuss your requirements and develop a customized toxicokinetic study protocol.

• Toxicology Assessment Services for Antidiabetic Drugs
• Safety Pharmacology Study Services for Antidiabetic Drugs

• Mouse Models
• Assay Kits
• Antibodies
• Cell Lines & Lysates
• Proteins & Peptides
• Inhibitors & Activators