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- In Vivo Models of Diabetes Mellitus
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OUR EXPERTISE
We offer a comprehensive portfolio of validated in vivo and in vitro diabetes models to support every stage of your preclinical research, from target validation to efficacy testing.
Validated Models
All our models undergo rigorous validation to ensure reliability, reproducibility, and relevance to human disease.
Custom Solutions
We develop customized models tailored to your specific research needs, providing unique insights for your drug candidates.
Comprehensive Analysis
Beyond model generation, we provide detailed phenotypic, biochemical, and histological analysis of your compounds.
IN VIVO MODELS
Our in vivo models accurately replicate various aspects of human diabetes and its complications, providing robust platforms for evaluating your therapeutic candidates.
Naturally occurring diabetic models that develop disease without experimental manipulation, closely mimicking human pathophysiology.
Non-obese Diabetic (NOD) mice
Goto-Kakizaki (GK) rats
Zucker Diabetic Fatty (ZDF) rats
Models developed through high-fat, high-sugar, or special diets to induce insulin resistance and type 2 diabetes phenotypes.
High-Fat Diet (HFD) induced obesity and diabetes
Western Diet models
High-fructose diet models
Models created through surgical procedures to induce diabetes or obesity-related conditions.
Partial pancreatectomy models
Bariatric surgery models
Adrenalectomy models
Models generated by chemical agents that selectively damage pancreatic beta cells to induce diabetes.
Streptozotocin (STZ) induced models
Alloxan induced models
Combination chemical protocols
Genetically modified models with targeted mutations or transgenes that result in diabetic phenotypes.
Knockout models (e.g., db/db, ob/ob mice)
Transgenic models
Humanized models
Specialized models that develop diabetes-related complications, enabling evaluation of disease progression and treatment.
Diabetic nephropathy models
Diabetic retinopathy models
Diabetic neuropathy models
Note: Our offerings are limited to modeling services, and do not include the shipment of live animals.
Our comprehensive validation services confirm that your diabetes models meet the highest scientific standards and regulatory requirements, providing you with reliable, reproducible data for your research programs.
IN VITRO MODELS
Our in vitro models provide robust, high-throughput platforms for early-stage drug discovery, target validation, and mechanistic studies.
Primary islets and immortalized beta cell lines for studying insulin secretion, beta cell function, and beta cell survival under various conditions.
Key Models:
Assays Available:
Cellular models of insulin resistance in various tissues to evaluate compounds that improve insulin sensitivity.
Key Models:
Adipocyte models (3T3-L1, primary adipocytes)
Myocyte models (L6, C2C12 muscle cells)
Hepatocyte models (HepG2, primary hepatocytes)
Assays Available:
Glucose uptake and utilization assays
Insulin signaling pathway analysis
Lipid accumulation and metabolism assays
OUR APPROACH
We provide end-to-end support for your diabetes research programs, from study design to data analysis and interpretation.
Our scientific experts collaborate with you to design optimal studies based on your research goals, compound characteristics, and regulatory requirements.
Our experienced technical team conducts studies in accordance with standardized scientific procedures, implementing rigorous quality control throughout every stage of the process.
Our scientific team provides expert consultation to help interpret results, discuss next steps, and design follow-up studies as needed.
We help select the most appropriate models for your research needs and perform validation studies to ensure they meet your specific criteria.
We provide comprehensive data analysis using advanced statistical methods, with clear, publication-ready reports and expert interpretation.
OUR CAPABILITIES
Beyond model generation, we offer a full suite of analytical services to characterize your compounds' effects.
Biochemical Analysis
Serum and plasma analysis for glucose, insulin, HbA1c, lipids, and other metabolic markers.
Histopathology
Tissue collection, processing, staining, and quantitative analysis of pancreatic and other relevant tissue.
Molecular Analysis
Gene expression, protein analysis, and pathway profiling to understand molecular mechanisms.
Physiological Monitoring
Metabolic cage studies, body composition analysis, and telemetry for continuous physiological monitoring.
Contact us today to discuss your specific research needs. Our scientific team will work with you to design the optimal study using the most appropriate diabetes models for your therapeutic approach.
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
