At Ace Therapeutics, we provide integrated services for safety pharmacology trials and early drug safety evaluations to support our client's antidiabetic drug development programs. Our team of experts identifies potential safety risks of drugs by helping clients explore the effects of antidiabetic drug candidates on the central nervous system, respiratory system, and cardiovascular system, among others. Our safety pharmacology services are available as standalone assessments or as part of our comprehensive toxicological analyses.
Safety pharmacology is an essential element of most small molecule development programs and is submitted along with general toxicology for IND applications. The aims of safety pharmacology as a key component of new drug development include:
Ace Therapeutics provides comprehensive safety pharmacology services for your preclinical antidiabetic drug development program. Our services include a range of in vitro and in vivo safety pharmacological studies, conducted in accordance with international regulations and the requirements of the Code of Practice for the Use of Laboratory Animals. Our integrated research strategy provides a comprehensive approach to identifying potential organ risks associated with antidiabetic drugs, offering valuable insights to inform effective decision-making in the early preclinical development phase.
Safety assessment of the central nervous system (CNS)
Spontaneous activity, behavioral changes, coordination functions, sensorimotor reflexes, temperature changes.
Safety assessment of the cardiovascular system
Electrocardiogram, blood pressure, heart rate, temperature and activity tests in awake animals.
Safety assessment of the respiratory system
Respiratory rate, tidal and minute volumes in rodents and non-rodents.
Safety assessment of the gastrointestinal system
Evaluation of gastrointestinal adverse reactions, evaluation of gastrointestinal mucosal damage.
Safety assessment of the urinary system
We offer kidney function tests, blood biochemistry and kidney injury biomarker tests.
Ace Therapeutics designs and executes safety pharmacology and toxicology studies tailored to meet your specific requirements. Our services are designed to assist you in obtaining reliable drug safety data, which is essential for the development of safe and effective antidiabetic drugs. Please contact us for more details.
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
