Key Preclinical Application Areas

• Antiviral Drug Efficacy Screening: Evaluation of nucleoside analogs (entecavir, tenofovir), direct‑acting antivirals (DAAs) for HCV, and novel capsid inhibitors, entry blockers, and polymerase inhibitors.
• Immunomodulatory and Immunotherapy Testing: Assessment of checkpoint inhibitors, TLR agonists, therapeutic vaccines, and CAR‑T or TCR‑engineered T‑cell therapies in immune‑competent models to evaluate restoration of anti‑viral T‑cell responses and breakthrough of immune tolerance.
• Fibrosis, Cirrhosis, and HCC Progression Modeling: Long‑term chronic infection studies tracking the transition from hepatitis to fibrosis and hepatocellular carcinoma.
• Vaccine Development and Immunogenicity Evaluation: Preclinical testing of prophylactic and therapeutic vaccine candidates (protein, mRNA, viral‑vector) in transgenic and humanized models.

You might be interested in...