Ace Therapeutics is dedicated to providing reliable preclinical services designed to support your research. In the field of glaucoma research, we offer custom excitatory amino acid carrier 1 (EAAC1) knockout (KO) mouse models as critical tools for unraveling the complexities of this debilitating disease and developing novel drugs.
The Role of EAAC1 in Glaucoma
EAAC1 is a glutamate transporter expressed in retinal ganglion cells (RGCs) and other neural cells, playing a crucial role in regulating glutamate levels in the retina. Dysfunctional glutamate transport can lead to excitotoxicity, a process implicated in RGC damage and the pathogenesis of glaucoma. Studies have shown that mice lacking EAAC1 exhibit RGC and optic nerve degeneration without elevated intraocular pressure (IOP), replicating key pathological features of normal tension glaucoma (NTG). These EAAC1 KO mice serve as valuable animal models for investigating NTG and related glaucoma subtypes.
Fig. 1 RGC degeneration in EAAC1 KO mice. (Akaiwa K, et al., 2018)
Ace Therapeutics' Custom EAAC1 KO Mouse Models of Glaucoma
We leverage our expertise to provide custom EAAC1 KO mouse models, empowering researchers to delve deeper into the complexities of glaucoma. By deleting or disrupting the Slc1a1 gene that is responsible for encoding the EAAC1 protein, our team of experienced scientists generates EAAC1 KO mouse models of glaucoma successfully.
EAAC1 KO Mouse Model Validation Services
- RGC loss assessment
- Optic nerve cupping and thinning evaluation
- IOP measurement
- Retinal oxidative stress marker detection
Comprehensive Preclinical Services for EAAC1 KO Mouse Models
Ace Therapeutics also offers a range of evaluation and application services utilizing our EAAC1 KO mouse models to support glaucoma mechanism studies and therapeutic development.
| Services | What We Can offer |
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| Ocular phenotyping |
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| Histopathology and immunohistochemistry |
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| Molecular analysis |
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| In vivo drug efficacy testing |
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As animal models of NTG, EAAC1 KO mice are useful for studying IOP-independent mechanisms of RGC loss. Ace Therapeutics can generate EAAC1 KO mice with specific genetic backgrounds or additional modifications to meet the unique requirements of your glaucoma research. Contact us now to learn how we can support your projects.
Reference
- Akaiwa K, et al. Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma. Invest Ophthalmol Vis Sci, 2018, 59(5): 2080-2089.