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H11-CYP11B1-hCYP11B2

Cat. No: CDM0112

Nomenclature: C57BL/6J-H11^{em1Cin (CYP11B1-hCYP11B2)}/

Strain State: Embryo cryopreservation

Gene Summary
Human Ortholog	CYP11B1, CYP11B2
MGI ID	88583
Gene ID	1584
Target Name	CYP11B2, CYP11B2
Synonyms	CPN2, ALDOS, CYP11B, CYP11BL, CYPXIB2, P450C18, P-450C18, P450aldo

Model Description
Description	These mice carry a targeted insertion of human CYP11B1 in the H11 locus, together with an engineered hCYP11B2 mutation, leading to deficient 11β-hydroxylase expression and activity.
Disease Connection	Hypertension
Phenotype(s)	3841959

! For research use only. Not intended for any clinical use.