PD-161570
Cat. No: CDIA-0764
CAS. No.: 192705-80-9
Size: 5 mg
| Product Details |
| Formula |
C26H35Cl2N7O |
| Molecular Weight |
532.51 |
| Appearance |
Solid |
| Purity |
99.04% |
| Smiles String |
O=C(NC(C)(C)C)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl |
| Storage & Handling |
| Shipping |
Room temperature. |
| Storage Powder |
-20 °C/3 years, 4 °C/2 years |
Description
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
! For research use only. Not intended for any clinical use.
Related Products
